High and ultra-high resolution

High-density array data allows scientists to employ reliable and statistically solid methods for automated detection of copy number changes (like CBS-based methods), but at the same time it poses a significant challenge from the point of view of realistic processing times and reasonable memory requirements. This problem can sometimes be solved by recommending the use of high-performance computers. Alternatively, data reduction techniques that visualize aberration regions, but drastically reduce access to probe-level data, can be employed. infoQuant solutions are different – they give you power to analyze high-density array data for copy number changes on an average PC and to visualize probe-level genome-wide measurements in a sensible and interactive manner at the same time.

With high density of array CGH and SNP data comes ability to detect micro-aberrations. However, sometimes different analytical approaches are needed to detect micro-anomalies vs. extended copy number changes. Our automated Copy Number detection module provides the power to detect both with the same set of settings so that you can achieve reliable, reproducible results, which is a critical factor in Cytogenetics. Our software even gives you power to automatically dismiss CNV regions frequently observed in HapMap reference samples, if you don't want CNVs to clutter the results.

High density arrays open the door for high-throughput Copy Number Variation (CNV) studies, where ability to fuse copy number data from hundreds or sometimes thousands of samples is key. Our solution for large-scale cross-sample studies, CGH Fusion, empowers researchers to analyze sets of high-density arrays for common copy number patterns. This capability can be utilized in disorder studies (cancer, developmental disorders etc) as well as CNV studies conducted on healthy patients. The results of such studies can be immediately used in routine cytogenetic tests via appropriate visualizations of oneClickCGH.

Users of SNP arrays also gain power of automated LOH detection and interactive visualization of allele-specific measurements with our software. This feature can be used as a stand-alone tool or in conjunction with Copy Number analysis visualizations for deeper insight.