oneClickCGH

Overview

infoQuant’s oneClickCGH^® is a novel platform-independent array Copy Number analysis software that provides easy to use yet comprehensive detection and reporting of copy number changes. Watch a series of recorded seminars on DNA Copy Number and LOH analysis and our product videos for more information.

Features

Intuitive, user-friendly Cytogenetic workflow

infoQuant has put years of experience in aCGH and SNP data processing in clinical laboratories behind oneClickCGH software in order to create a simple, but efficient tool that helps report DNA copy number changes. oneClickCGH stands out among other commercial copy number analysis software packages due to its straight-forward user interface and workflow and comprehensiveness of its reporting features. In a few clicks users can go through multiple stages of advanced data processing and start browsing through automatically detected gains, losses and LOH regions.

Comprehensive report document

Detected copy number changes can be added to the final report and manually edited, if needed. User can then add clinical sample information, region annotation and other kinds of useful records to the report. And finally, test results can be saved as a comprehensive and graphics-rich Word document, PDF file or a compact Excel table.

Flexible data import

oneClickCGH is compatible with data formats used by all major array CGH and SNP platforms: PerkinElmer, Agilent, Affymetrix, Nimblegen, Illumina, BlueGnome and more. oneClickCGH is the only user-friendly aCGH software supporting both BAC arrays and high-resolution oligo platforms.

Now with integrated LOH detection

Our workflow integrates LOH detection with Copy Number analysis for the users of SNP arrays. Utilizing allele-specific measurements oneClickCGH provides reliable and meaningful LOH calls suitable for cancer studies with Affymetrix and Illumina platforms.

New level of data interaction

State-of-the-art interface instantly connects several visualization tools: from ratio and allele-specific plots to array image to report table. Detected aberrations can be edited and reviewed in a fully interactive manner, which makes Copy Number informatics a simple and intuitive process.  oneClickCGH also interfaces with publicly available knowledge databases like Entrez, Database of Genomic Variants, UCSC genome browser and other for efficient interpretation of the results.

Integrated gene information and CNV tracks

Gene information is integrated directly into our data visualization tools to facilitate user-friendly reference to known genes, their associations with various disorders and gene ontology terms. We have also integrated known CNV tracks from public sources into oneClickCGH. This ensures that our users can make insightful inferences regarding clinical relevance of detected anomalies with minimum effort. And finally, integration of custom in-house CNV tracks can make aberration reporting even more productive turning oneClickCGH into an ultimate Cytogenetic software package.

Advanced statistical analysis

oneClickCGH employs modern methods of statistical analysis throughout its workflow: from data normalization to analysis of significantly affected genes. Our method of Robust Binary Segmentation developed together with leading Cytogenetic laboratories delivers reliable and consistent detection of chromosomal anomalies. Analysis of gene significance delivers a short list of genes and ontology terms affected by detected aberrations. 

Share results with oneClickCGH Viewer

oneClickCGH Viewer is a free collaboration-enabling tool for users that wish to share their results generated through oneClickCGH or CGH Fusion with their colleagues within or outside their institution. oneClickCGH Viewer software, while not as powerful as oneClickCGH, provides a graphics-rich and informative display of array data and detected anomalies saved during an analysis session of the full version of our analytical software. As a result, our users can communicate with their peers freely and efficiently.

Screenshots

Detected Aberration with CNV Annotations

System Requirements