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infoQuant's CGH Fusion® is the leading software for DNA Copy Number and LOH analysis designed with high-throughput diagnostic laboratories in mind. CGH Fusion is the ultimate end-to-end data analysis solution that facilitates processing of large batches of array CGH and SNP array data taking productivity of a Cytogenetic lab to the next level. With CGH Fusion you can not only analyze large sets of arrays with a single click, but also compare results across samples, detecting common DNA anomalies quickly and reliably.

Features

Unsupervised batch processing

Batch data analysis can be executed on data generated with aCGH and/or SNP array platforms for dozens or hundreds of samples with a single mouse click. infoQuant's platform-specific approach to data normalization and segmentation allows you to process sets of array data on a standard PC producing automated gain/loss and LOH calls for the whole dataset within minutes.

Centralized array CGH analytics

With CGH Fusion clinical laboratories can benefit from centralized processing of array data reducing their risk of human error. Analysis results from a specific batch are automatically saved locally, to a local or shared hard drive or to a database, where they can be reviewed and interpreted later on. This type of organization in data processing is especially useful for laboratories employing multiplex chips. Additional seats of oneClickCGH software can help laboratories to further organize their review and approval workflow around CGH Fusion.

Compatibility with major array platforms

CGH Fusion is compatible with data formats used by all major aCGH and SNP platforms: PerkinElmer, Agilent, Affymetrix, Roche-Nimblegen, Illumina, BlueGnome, OGT and more. It is the only array software supporting both BAC and oligo array platforms with the highest level of precision and interaction. Such platform independence enables researchers and clinicians to compare genomic variation regions for array datasets generated by different labs or even different institutions. CGH Fusion will keep supporting your Copy Number analysis needs no matter which array platform you decide to migrate to in the future.

Unprecedented level of data interaction

CGH Fusion was designed for unprecedented data interaction experience and ease of use. This software was built to help you navigate across different samples and to let you drill any anomaly down to the probe level of an individual sample for instant visualization. CGH Fusion also allows you to visually compare probe-level data between samples and to visualize both copy number and allele-specific measurements at the same time. Its reporting interface is enriched with gene information, disorder associations, Gene Ontology terms and publicly available CNV tracks. All that information is right there at your fingertips to provide the most effective path to clinical interpretation of the results.

Custom-built CNV tracks

CGH Fusion is the only array copy number software that can turn a tedious procedure of accumulating in-house sets of known copy number variants into a simple and interactive task. It allows its users to build sets of normal or phenotype-specific Copy Number Variants (CNVs) utilizing large collections of samples. Seamless integration with oneClickCGH makes then custom CNV tracks available for reference in routine diagnostic tests. This facilitates constant interaction between research and diagnostic processes within an institution.

Power of data fusion across samples

CGH Fusion helps geneticists identify and visualize gain/loss and LOH regions that are common across patients with similar medical conditions constructing comprehensive copy number patterns. Using CGH Fusion you can also easily compare copy number variations across different groups of patients producing valuable biological insights within minutes. Data from different array platforms can be easily compared in CGH Fusion within the same dataset.

Screenshots

Multi-sample comparison

Multi-sample comparison

 

Using annotation plots for data interpretation

Using annotation plots for data interpretation

 

Interacting with report table

Interacting with report table

 

Report document

Report document

 

Anomaly frequency plot

Anomaly frequency plot

 

System Requirements

  • Windows XP+, OS X 10.6+, Linux with Java 1.6+
  • 2GHz or greater CPU
  • 2GB or greater RAM
  • 1024x768 or higher display
Supported Platforms - windows, osx, linux

Additional Resources

Evaluations and Online Demonstrations

infoQuant provides 14 day evaluations as well as one-on-one online demonstrations for oneClickCGH and CGH Fusion. Please complete our evaluation request form  to participate.